• Another interesting finding regarding substrate selectivity

  2020-04-07

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty 89 6 receptor at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitu

• br Rationale and hypothesis To discover an allosteric

  2020-04-07

  

  Rationale and hypothesis To discover an allosteric inhibitor of EGFR, Jia et al. (2016) screened a library of 2.5 million compounds at 1 μM ATP concentration in opposition the purified EGFR L858R/T790M mutant enzyme. 1322 best hits were found from this round of screening. The pinnacle hits had be

• br EBV BILF A Virus

  2020-04-07

  

  EBV-BILF1—A Virus-Encoded 7TM Receptor with Immune Evasive Functions The EBV-encoded BILF1 receptor (EBV-BILF1) is thought to be implicated in the immune evasion strategy of EBV.56, 61, 62 This orphan 7TM receptor is expressed at significant levels during the early lytic phase of the virus infect

• Targeting both PARP and DHODH for anti

  2020-04-07

  

  Targeting both PARP-1 and DHODH for anti-cancer therapy would certainly be beneficial as these enzymes share a common role in the DNA replication and repair mechanisms which are involved in the hyper-proliferation of cancer cells. Since benzimidazole-containing compounds have been reported to show g

• In the PTEN loss mouse model deletion

  2020-04-07

  

  In the PTEN loss mouse model, deletion of ATG7 gene not only caused an autophagy-deficient phenotype, but also postponed the progression of inoculated prostate tumor [22]. On the basis of these experimental facts, these ATG7 and PTEN related genes were then compared with the 3020 BCR-associated gene

• The interaction of EPAC with

  2020-04-06

  

  The interaction of EPAC2 with Rim1 has an important role in regulating neurotransmitter release. In addition, a recent EPAC2 knockout mice model study provides evidence that EPAC2 promotes transmitter release by maintaining the readily releasable pool (RRP) at mossy fiber (MF) synapses in the hippoc

• Recent reports revealed that CSE

  2020-04-06

  

  Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including 2825 [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of inflammatory

• The contribution of local ETA

  2020-04-06

  

  The contribution of local ETA and ETB receptors towards heat hyperalgesia induced by inoculation of XC tumor Y 134 in the paw of mice has been demonstrated by Baamonde and colleagues (Baamonde et al., 2004). Furthermore, using neuropathic and inflammatory nociception models, several studies have sh

• To examine the influence of aromatic motifs on the bridging

  2020-04-06

  

  To examine the influence of aromatic motifs on the bridging lysine esters we analysed DNA alkylating activity of the set of compounds 1–6. The lysine derivatives were chosen as it is relatively easy to prepare different esters and thereby study the impact of different groups on the reactivity toward

• One step in pyrimidine biosynthesis is

  2020-04-06

  

  One step in pyrimidine biosynthesis is conversion of l-dihydroorotate (DHO) to orotate (ORO), under action of the enzyme dihydroorotate dehydrogenase (DHODH, EC 1.3.99.11), which contains a flavine (FMN) as redox cofactor [1]. In this transformation, electrons resulting from DHO oxidation are transf

• The only in vivo evidence for a role of DDR

  2020-04-06

  

  The only in vivo evidence for a role of DDR2 in fibrotic disease showed that DDR2 knockout mice exhibited exaggerated severity of chronic hepatic fibrosis. Although a previous in vitro study has demonstrated that DDR2 promotes lung fibroblast proliferation and migration, till now it remains unclear

• Addition of deoxyuridine to CY cultures led

  2020-04-06

  

  Addition of deoxyuridine to CY11 cultures led to a significant decline in the amount of uracil-DNA (Fig. 5). Deoxyuridine effectively induces the deo operon and is efficiently degraded to uracil and deoxyribose 1-phosphate by the deoA gene product, thymidine phosphorylase; a minor percentage of deox

• The strong adsorption of amines

  2020-04-06

  

  The strong adsorption of amines to the stationary phase of gas chromatography (GC) columns causes issues such as tailing, ghosting and low reproducibility [12], [13]. A common practice to overcome this problem is the chemical derivatisation of amines prior to GC analysis [14]. Comprehensive reviews

• Introduction Human cytomegalovirus CMV is a herpesvirus whic

  2020-04-06

  

  Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss

• Noteworthy the transient downregulation of the regulatory CK

  2020-04-06

  

  Noteworthy, the transient downregulation of the regulatory CK2β subunit reduces HSP27 expression in all the three different human cell lines (Fig. 2b). Similarly, the downregulation of one of the two catalytic subunits, CK2α or CK2α′, is sufficient to affect HSP27 expression without affecting other

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