• Accordingly it is tempting to speculate

  2021-10-28

  

  Accordingly, it is tempting to speculate that the maintenance of a stimulus representation in the A2 state for a short period of time after the presentation of a specific stimulus (i.e. self-generated priming) may rely upon GluR-A-dependent synaptic plasticity. If this were the case, GluR-A mw calc

• br Origin of the vertebrate hexokinase gene family

  2021-10-28

  

  Origin of the vertebrate hexokinase gene family Multiple hexokinases have been found in vertebrates, plants and yeast (Wilson, 1995, Cárdenas et al., 1998). A hexokinase in both vertebrates and yeast has, unfortunately, been named glucokinase. The sharing of the name glucokinase has suggested to

• The findings in mice were echoed in the human

  2021-10-28

  

  The findings in mice were echoed in the human studies, in which the effects of higher doses of LY3298178 caused greater weight loss than the selective GLP-1RA dulaglutide. In patients with T2DM, LY3298176 demonstrated meaningful weight loss after only four weeks of treatment. This was consistent wit

• br Conclusion br Conflict of Interest JJH has collaborated w

  2021-10-28

  

  Conclusion Conflict-of-Interest JJH has collaborated with several different pharmaceutical companies during the last 30 years; is currently receiving speaker honoraria from NovoNordisk and MSD and is on advisory boards for NovoNordisk. The author is currently supported by an independent grant

• estrogen receptor antagonist With rare exceptions the biolog

  2021-10-28

  

  With rare exceptions, the biological role of γ-secretase cleavage of substrates other than Notch 1 has been ignored during proof of concept preclinical repurposing studies. For example, in the GSI AD trial, many individuals noted changes in hair color, apparently due to inhibition of tyrosinase, ano

• Thirteen multiparous German Holstein cows

  2021-10-28

  

  Thirteen multiparous German Holstein cows, in their second to fourth lactation, were selected from a previous study (Schäff et al., 2012) based on their individual peak in plasma BHB concentrations in wk 2 or 3 postpartum: high BHB (H-BHB; 1.05 to 2.57 mmol/L, mean 1.59 mmol/L; n = 8) and low BHB (L

• DL-AP5 Sodium salt br Materials and methods br Results

  2021-10-28

  

  Materials and methods Results Discussion Induction of neuronal cell death is the main neurotoxic mechanism of arsenite (Vahidnia et al., 2007). Previous studies have demonstrated that arsenite may trigger neuronal cell death via apoptosis, autophagy as well as necrosis (Yen et al., 2012; La

• The minimal segment of the

  2021-10-28

  

  The minimal segment of the SIM appears to be a core of Argatroban residues, which frequently matches the consensus sequences ΨΨΨΨ, ΨxΨΨ, or ΨΨxΨ (where Ψ is V, I, or L and x is typically D, E, S, or T) [29,31,32]. In a subset of SIMs, this hydrophobic core is flanked by serine residues and a stretc

• Here we showed that microinjection

  2021-10-28

  

  Here we showed that microinjection of siRNA at the MII stage efficiently reduced endogenous EZH2 mRNA and protein. Although the percentage of cleaving embryos was not affected, PMX 205 formation and blastocyst cell number were both reduced in EZH2 knockdown groups (Table 1). Similar results have be

• Our results on the other

  2021-10-28

  

  Our results, on the other hand, shows that there is no upregulation of ETBR on the spinal cord after SCI, but there is a significant difference of mRNA on days 2, 7 and 28 on the SCI group on the spinal cord and no changes on the DRG, suggesting that the spinal cord injury may reduce the renovation

• br Material and methods br Results br

  2021-10-27

  

  Material and methods Results Discussion Liver plays a key role in the metabolism and detoxification of DON (Peng et al., 2017). However, various DON investigations generated inconsistent results, with some showing hepatotoxicity of DON, while others not. For example, one report stated that

• ICLs represent of all generated DNA adducts

  2021-10-27

  

  ICLs represent ICL Inducers in Cancer Therapy Nitrogen mustards with aromatic substituents (chlorambucil, melphalan) or a bioactivatable phosphoramide group (cyclophosphamide) were one of the first identified DNA crosslinkers. These agents are still used in combined schemes for the therapy of chr

• Elimination of the Q R bridge significantly affected

  2021-10-27

  

  Elimination of the Q234–R244 bridge significantly affected the protein chemokine receptor antagonist but had little effect on its activity at a permissive temperature, which may seem contrary to the known functional importance of this motif in Fpg. However, since the mutants fully or partially reta

• br Material and methods br

  2021-10-27

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new PPADS tetrasodium salt with different structures have been synthesize

• Human GS is a multi subunit

  2021-10-27

  

  Human GS is a multi-subunit complex consisting of four components: presenilin 1 (PS1), presenilin enhancer 2 (PEN-2), anterior pharynx-defective 1A (APH-1A) and nicastrin (NCT) (Fig. 1a) [5,6]. PS1 comprise nine transmembrane helices (TM 1–9) and contains the catalytic aspartate residues in its TM6

15043 records 573/1003 page Previous Next First page 上5页 571572573574575 下5页 Last page