• We used a culture model of human

  2022-03-04

  

  We used a culture model of human erythropoiesis that recapitulates all developmental stages [24] to screen a focused set of lncRNAs for potential contribution to this program. We found induction of lncRNA Fas-antisense 1 (Fas-AS1 or Saf) during RBC maturation and demonstrate that essential erythroid

• The relationship between the attention deficit

  2022-03-03

  

  The relationship between the attention deficit hyperactivity disorder (ADHD) and H3Rs is supported by several reports (Berlin et al., 2011; Passani, Bacciottini, Mannaioni, & Blandina, 2000; Vohora & Bhowmik, 2012). ADHD is a neurobehavioral disorder with high prevalence in children, with hyperactiv

• HO acted as an intracellular defender against

  2022-03-03

  

  HO-1 acted as an intracellular defender against oxidative stress-induced cell damage. To elucidate the effects of HO-1 in ropivacaine-induced cytotoxicity in neuronal cells, HO-1 activity was inhibited using a specific HO-1 inhibitor zinc protoporphyrin, ZnPP. Our results indicate that ZnPP treatmen

• Acknowledgements We appreciated the contributions of

  2022-03-03

  

  Acknowledgements We appreciated the contributions of Ana Carolina Galha, Selma XSL Pinheiro and Islene Azevedo for technical assistances. In addition, we wish to thank Adilson José de Almeida (in memoriam), Moyra M Portilho, Vanessa A Marques and Letícia P Scalioni, for data analysis during the set

• Here we show that CT recruits multiple Rab GTPases

  2022-03-03

  

  Here, we show that CT229 recruits multiple Rab GTPases and Rab effector proteins to the inclusion; the CT229 Inc protein redirects and intercepts host clathrin-coated vesicles (CCVs). CT229 is required for recruitment of transferrin (Tfn) positive CCV’s from the recycling pathway to the periphery of

• Many studies have reported on

  2022-03-03

  

  Many studies have reported on the association between GST gene polymorphisms and pulmonary disorders but with controversial results [7]. In the present study, on comparing results of GSTP1 gene polymorphism among the studied COPD patient groups, it was found that heterozygote mutation was significa

• GPR belongs to the G protein coupled receptor family

  2022-03-03

  

  GPR84 belongs to the G protein-coupled receptor family, and it was first identified from human peripheral blood neutrophils [,]. GPR84 is now considered to be a member of receptor for medium chain fatty prostaglandin receptor (MCFA) with carbon chain lengths of 9–14 []. GPR84 is mainly expressed in

• We recently reported that the human

  2022-03-03

  

  We recently reported that the human-derived PancCa cell line PANC-1 and the human-derived hepatocellular HepG2 cell line express GPR55 mRNA and protein [21]. In PANC-1 and HepG2 cells, knockdown of GPR55 with specific siRNAs abrogates cellular uptake of Tocrifluor 1117, a selective GPR55 ligand [21]

• TGR is a class A

  2022-03-03

  

  TGR5 is a class A GPCR, transducing signal through Gs-protein mediated cAMP accumulation, and was recently reclassified as the founder member of the bile–acid receptor subclass of GPCRs [22]. The cAMP-mediated signaling of TGR5 activation has been implicated in a range of cellular physiological acti

• br AUTHOR CONTRIBUTIONS br ACKNOWLEDGMENTS br Introduction C

  2022-03-03

  

  AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS Introduction Chronic neuropathic pain is a common symptom in patients with human immunodeficiency virus (HIV)-1 infection. Glycoprotein 120 (gp120) is an HIV-1 protein that can cause pain behaviors in animal models (Hao, 2013, Nasirinezhad et al., 2015,

• br Significant efforts are currently

  2022-03-03

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) citco receptor hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing syn

• br Perspectives br Contributors BP study concept design

  2022-03-03

  

  Perspectives Contributors BP: study concept & design, literature review, data analysis & synthesis & presentation, primary draft of the manuscript; JDR: data analysis, Fig. 1 illustration, manuscript review & revision; ZP: study concept & design, manuscript review & edit; MI: manuscript review

• br Endogenous lipids as SLC

  2022-03-03

  

  Endogenous lipids as SLC6 transporter modulators Lipids constitute part of the environment in which membrane-embedded transporters operate [62]. Endogenous lipids can act as inhibitory ligands [63] or functionally important components of the membrane that impart changes in transporter structure [

• br Methods GLUT DS was

  2022-03-03

  

  Methods GLUT1DS was diagnosed either when analysis of the SLC2A1 gene showed a pathogenic mutation and/or when cerebrospinal fluid (CSF) analysis met the criteria for GLUT1DS: a CSF VUF 11207 fumarate mg below the 10th percentile, a cerebrospinal fluid (CSF) to blood ratio below the 25th percenti

• br Genetic rescue of GluR

  2022-03-03

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Abiraterone mg of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005

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