• Cellular detoxification is an important process that

  2023-01-10

  

  Cellular detoxification is an important process that helps remove excess oxidants from the cellular environment through endogenous antioxidants or other molecules capable of reduction. One of the key regulators of antioxidant production is the transcription factor, nuclear factor (erythroid-derived

• Although only Leu CysAP IRAP

  2023-01-09

  

  Although only Leu/CysAP (IRAP) (Herbest et al., 1997, Keller, 2004) and DPPIV (Alponti and Silveira, 2010, Kirino et al., 2009) had been identified and studied in adipocytes, our kinetic analysis suggested the highest physiological significance for AspAP (highest affinity) and APM and PSA (highest e

• br Conclusions br Acknowledgments The authors are thankful

  2023-01-09

  

  Conclusions Acknowledgments The authors are thankful to Hugo Santos, Olga Martinez and Ricardo Lacerda for the technical assistance provided in the maintenance of the aquaria. This work was supported by national funds, through FCT and co-funded by the European Regional Development Fund (ERDF)

• br Methods br Results br Discussion First the cells isolated

  2023-01-09

  

  Methods Results Discussion First, the EZ Cap Reagent AG isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed tha

• br LOX in esophageal cancer Various studies suggest that

  2023-01-09

  

  5-LOX in esophageal cancer Various studies suggest that abnormal levels of AA metabolites play an essential role in human esophageal adenocarcinogenesis (EAC). The key AA derivatives of 5-LOX signaling molecules namely include, 5-HETE, LTB4, and cysteinyl LTs, which are well-known to initiate inf

• In conclusion we report that

  2023-01-09

  

  In conclusion, we report that the widely prescribed drug VPA exerts therapeutic effects on optic nerve demyelination and retinal degeneration in a mouse model of MS. Our findings raise an interesting possibility that combination therapy of VPA and ASK1 inhibition may be useful for treatment of autoi

• br Apelin The APJ receptor

  2023-01-09

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino TCS JNK 6o synthesis residues that are cleaved into biologically active C-terminal fragments of v

• On the other hand our study permits to

  2023-01-09

  

  On the other hand, our study permits to draw general conclusions about the complex functional pattern of C4HT, C8HT and C12HT, in comparison with the parent molecule HT and two reference compounds like Trolox and vitamin E. Table 1 summarizes the results obtained in the present investigation (for th

• The leaves of Bambusa nutans

  2023-01-09

  

  The leaves of Bambusa nutans, B. vulgaris, B. textilis McClure, B. vulgaris var. vittata, and Dendrocalamus oldhami are reported as promising natural alternatives to synthetic antioxidants as functional food ingredients (Tripathi et al., 2015). Luo et al. (2015), identified two novel flavonoids name

• The zinc transporter proteins are members of

  2023-01-09

  

  The zinc transporter proteins are members of the SLC superfamily of metal transporters, and comprise two structurally and functionally different groups, the zinc-importer (ZIP; Zrt-, Irt-like proteins) family (SLC39A), which regulate zinc transport into the cytoplasm from outside the cell and from i

• br Acknowledgments and Disclosures br Alzheimer s

  2023-01-09

  

  Acknowledgments and Disclosures Alzheimer's disease as a synaptic pathology Alzheimer's disease (AD) is a chronic neurodegenerative natural antibiotics disorder and the most common cause of dementia in the elderly. Progressive depositions of amyloid plaques and neurofibrillary tangles togethe

• br Experimental Procedures br Acknowledgments br

  2023-01-09

  

  Experimental Procedures Acknowledgments Introduction Cellular and molecular mechanisms underlying synaptic plasticity in the AMG-458 are thought to be involved in memory acquisition. Synaptic plasticity is categorised into two main types, long-term depression (LTD) and long-term potentiati

• Platelet derived growth factor PDGF and ciliary neurotrophic

  2023-01-09

  

  Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial FLAG Peptide receptor and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation

• Inhibition of autophagy has been shown to alleviate neuronal

  2023-01-09

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• br Introduction There are greater

  2023-01-09

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

14951 records 357/997 page Previous Next First page 上5页 356357358359360 下5页 Last page