• Perforation of the surface membrane

  2023-06-26

  

  Perforation of the surface membrane, however, is not the only mechanism of calcium dysregulation by Aβ at the presynaptic terminals. When in excess, both monomers and oligomers modulate biophysical properties of voltage-activated calcium DPQ mg as well as calcium release from the endoplasmic reticu

• br ABCA is a sterol responsive gene The first evidence

  2023-06-19

  

  ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl

• Oxidative stress has recently been reported as one

  2023-06-16

  

  Oxidative stress has recently been reported as one of the important mechanisms of toxic effect of Cd2+[43]. The mechanism of Cd2+-induced oxidative stress involves an imbalance between generation and removal of ROS in tissues and cellular components, causing damage to membranes, DNA, and proteins [4

• Although effects of low concentrations of

  2023-06-15

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major Meropenem trihydrate α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-estera

• aphidicolin synthesis At present the role of autophagy in ne

  2023-06-13

  

  At present, the role of autophagy in neurons remains controversial. Autophagy has homeostatic and waste-recycling functions and plays a protective role in neurodegeneration diseases. Moreover, it has been thought as a programmed cell death participating in the occurrence and development of various d

• At first the APC is a kDa protein divided into

  2023-06-13

  

  At first, the APC is a 310kDa protein divided into three domains such as N-terminal, central core and C-terminal domain [102], plays a major role to regulate the Wnt signaling pathway in human cancer by translating β-catenin from the BAY 87-2243 receptor to the nucleus [103]. The SIRT1 regulates th

• The isoelectric point of CL ARG was determined

  2023-06-09

  

  The isoelectric point of CL-ARG was determined by native IEF at a Ac-IETD-pNA gradient in the range (3–10) using standard protein markers with known isoelectric points. Native IEF reveals the presence of only one major band for CL-ARG with a slightly neutral-basic pI value of about 7.7. The calcula

• In AD and possibly other forms of dementia it has

  2023-06-03

  

  In AD, and possibly other forms of dementia, it has been suggested that tau mislocalization to dendritic spines anticipates neurodegeneration [48]. Accumulation of hyperphosphorylated tau in dendritic spies would cause a derangement of synaptic function, thereby impairing excitatory synaptic transmi

• To examine whether the interaction between

  2023-06-02

  

  To examine whether the interaction between mGlu7 and α1-adrenergic receptors could be confirmed at a behavioural level, we performed the FST in mice. This test has value in predicting the antidepressant-like effect of drugs or environmental manipulations (Krishnan and Nestler, 2008, Krishnan and Nes

• Our published data showed that in mouse heart the protein

  2023-05-31

  

  Our published data showed that, in mouse heart, the protein level of WDR1 was highest during the embryonic stage, but became progressively decreased to a constant level from birth to adulthood (Yuan et al., 2014), indicating an important role of WDR1 in embryonic heart development. However, function

• Liproxstatin-1 br Conflict of interest statement br Benign

  2023-05-30

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal Liproxstatin-1 in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellula

• Inhibitors of mPGES are considered

  2023-05-30

  

  Inhibitors of mPGES-1 are considered as safe alternative to NSAIDs in the treatment of chronic inflammatory diseases that are characterized by excessive PGE2 production (Bahia et al., 2014; Khurana and Jachak, 2016; Koeberle et al., 2016; Korotkova and Jakobsson, 2014; Norberg et al., 2013; Psarra e

• We have previously shown that the antinociceptive effect of

  2023-05-30

  

  We have previously shown that the antinociceptive effect of tramadol, an analgesic that, like paracetamol is able to increase serotonin levels within CNS, is potentiated or antagonized respectively by a 5-HT1A/B nonspecific Chlorothiazide blockade or activation (Rojas-Corrales et al., 2000). Moreove

• br Materials and methods br Results The

  2023-05-30

  

  Materials and methods Results The clinical characteristics of the two selected groups are shown in Table 1. As shown in Table 1, the enzyme activity of ATX in CSF of MS patients (59.90±3.09nmol/min/ml±SEM) was significantly higher (p Discussion Numerous studies have so far shown that ATX tak

• Thalidomide is now a well known antiangiogenic agent This

  2023-05-29

  

  Thalidomide is now a well known antiangiogenic agent. This property of thalidomide is being extensively researched upon, for its significant utility in the treatment of various malignant tumors. Studies show that thalidomide efficaciously inhibits various pro-angiogenic factors such as tumor necrosi

14950 records 321/997 page Previous Next First page 上5页 321322323324325 下5页 Last page